PM stands for Polymeric Micelle is a low molecular weight, biodegradable amphiphilic diblock copolymer, mPEG-DPLLA ( methoxy-Poly Ethylene Glycol - Poly (D,L-Lactide) with Lactose anhydrous ) which has 2 segments, hydrophilic and hydrophobic. The Hydrophobic segment of PM assemble with the active ingredient, paclitaxel performing a core structure, while its hydrophilic segment acts as the biodegradable shell which make the PM complex soluble in physiological solution.
* (Kim TY, Clin Cancer Res 2004;10:3078-3716)
Copolymer is a polymer derived from two (or more) monomeric species, as opposed to a homopolymer where only one monomer is used.
A polymer is a large molecule (macromolecule) composed of repeating structural units typically connected by covalent chemical bonds.
A covalent bond is a form of chemical bonding that is characterized by the sharing of pairs of electrons between atoms, or between atoms and other covalent bonds. In short, attraction-to-repulsion stability that forms between atoms when they share electrons is known as covalent bonding.
A micelle is an aggregate of surfactant molecules dispersed in a liquid colloid. A typical micelle in aqueous solution forms an aggregate with the hydrophilic "head" regions in contact with surrounding solvent.
*( J. M. Seddon, R. H. Templer. Polymorphism of Lipid-Water Systems, from the Handbook of Biological Physics, Vol. 1, ed. R. Lipowsky, and E. Sackmann. (c) 1995)