PAXUS™ PM Patient Information

Before you begin treatment with PAXUS™ PM, read these pages only as initial information. Your doctor, pharmacist and nurse are always your best source of information about your condition and treatment. If you have additional questions or concerns, be sure to ask them. PAXUS™ PM should be given under the supervision of a doctor experienced in the use of anti-cancer drugs.

What is PAXUS™ PM ?

Active pharmaceutical ingredient of PAXUS™ PM, is paclitaxel which belongs to the group of medicines called antineoplastics. This particular paclitaxel product contains no toxic solvents, unlike other conventional paclitaxel products. This may reduce some of the adverse effects such as allergic reactions that may be caused by these solvents other ingredients, however, PAXUS™ PM, may still cause severe allergic reactions in rare cases which require other medications to treat such allergic reactions.


About the Medication

What the medication is used for:

PAXUS™ PM is used for:

  • advanced or recurrent breast cancer
  • locally advanced non-small cell lung cancer in combination with carboplatin
  • advanced ovary cancer, when used in combination with carboplatin


When it should not be used:

PAXUS™ PM should not be used if:

  • you have had an allergic reaction to paclitaxel or to methoxypolyethylene glycol-poly D,L lactic acid or any of the other ingredients in the product
  • you have a low white blood cell counts (neutropenia) or less than 1,500 cells/mm3. To make sure that your blood counts are in the proper range, you will be asked to have frequent tests.
  • you have a severe liver disease
  • you are pregnant or breast-feeding


What the medicinal ingredient is:

The active ingredient in PAXUS™ PM is paclitaxel.


What the nonmedicinal ingredients are:

The non-active ingredients are methoxy polyethyleneglycol-poly D,L lactic acid.


What dosage forms it comes in:

PAXUS™ PM is supplied as a white to yellowish, lyophilized powder or light porous mass for reconstitution in a glass vial. Packaging in a vial of 30 mg or 100 mg of paclitaxel.



Before you use PAXUS™ PM

Before you use PAXUS™ PM, talk to your doctor or pharmacist if:

  1. you are experiencing numbness or tingling in your extremities
  2. you suspect that you are pregnant, plan to become pregnant or are nursing. PAXUS™ PM can cause harm to the fetus. Avoid becoming pregnant while taking PAXUS™ PM and if you become pregnant during treatment, contact your doctor immediately
  3. you are breast-feeding or plan to breast-feed. Your doctor may advise you not to breast-feed while taking PAXUS™ PM you have any allergies to this drug or its ingredients or components of the container.



Side effects and what to do about them

Most patients taking PAXUS™ PM will experience side effects, although it is not always possible to tell whether such effects are caused by PAXUS™ PM, another medicine they may be taking, or the cancer itself. Report any unusual symptoms to your doctor.

Serious side effects observed in studies of patients taking PAXUS™ PM were as follows:

  • Infections Due to Low White Blood Cell Count: Among the body’s defenses against bacterial infections are white blood cells. PAXUS™ PM usually causes a brief drop in white blood cells. If you have a fever (temperature above 100.4°F/38°C) or other sign of infection, tell your doctor right away.
  • Numbness, Tingling, or Burning (Neuropathy): These symptoms in the hands and/or feet occur often with PAXUS™ PM and usually get better or go away without medication within three weeks of interrupting treatment.
  • Respiratory: PAXUS™ PM may cause shortness of breath and cough.
  • Allergic reaction: PAXUS™ PM may cause mild allergic reactions during the infusion such as flushing.

Common side effects were as follows:

  • Hair Loss
  • Changes in heart beat and blood pressure
  • Tiredness and Weakness
  • Joint and Muscle Pain
  • Low Red Blood Cell Count (anemia): Red blood cells deliver oxygen to the tissue. Patients can feel tired, tire easily, appear pale, and become short of breath. Contact your doctor if you experience any of these symptoms following PAXUS™ PM treatment.
  • Mouth or Lip Sores (Mucositis)
  • Stomach Upset and Diarrhea

Talk with your doctor or other healthcare professional to discuss ways to prevent or reduce some of these side effects. Because this information does not include all possible side effects that can occur with PAXUS™ PM, it is important to talk with your doctor about other possible side effects.



PAXUS™ PM is underlicensed of Samyang Biopharmaceuticals, Inc. for Kalbe International. Pte., Ltd.

 

This product is for prescription only. For availability of the product please contact us.
Brand Name: PAXUS™ PM (South East Asia), GENEXOL® PM (Korea & other territories)